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However, because intra‐amygdala injection cannot be a part of the response to systemic GLP‐1, we have to assume that adverse effects seen in response to systemically administered GLP‐1 receptor agonists are different to those elicited by activation of GLP‐1 receptors behind the BBB

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But reconstituted peptides in solution, which is what semaglutide pens and vials contain, cannot tolerate freezing